Depo-Medrol Side Effects

Depo-Medrol is the brand name in the United States for the generically named medication methylprednisolone. It may be used for a variety of ailments, Drugs.com states, including adrenal gland problems, asthma or allergies that occur in severe form, ulcerative colitis, multiple sclerosis and other maladies. The medicine classifies as a corticosteroid that works to reduce inflammation. Depo-Medrol may be administered via injections and it can cause some side effects.

Menstruation Changes

Women who take Depo-Medrol may have their menstrual cycles disrupted by the medicine, MedlinePlus indicates. The drug can cause irregularity of periods. She also may experience amenorrhea, or a lack of menstruation. These side effects classify as non-serious and will usually subside without treatment. MedlinePlus suggests consulting the physician if menstrual changes occur severely or if they do not end.

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Fatigue

The use of Depo-Medrol may induce a feeling of fatigue, usually when the person begins treatment. He may experience the same types of tiredness and physical exhaustion commonly associated with hard work or exercise. Side effects such as fatigue and tiredness should occur in a mild form, Drugs.com indicates. They also should disappear as the person's body system becomes used to the medication. The person should contact his doctor, however, if the use of Depro-Medrol causes significant or persistent fatigue.

Mental Difficulties

During the initial treatment with Depo-Medrol, changes in mental state may be experienced. The patient may feel restless and anxious, MedlinePlus reports. She may notice mood changes. She also may become depressed with feelings of emptiness and sadness. These effects tend to occur only when treatment begins; symptoms should subside without intervention.

Skin Problems

The person using Depo-Medrol may experience new outbreaks of acne or, if he has acne already, an increase in breakouts. Skin may appear thinner than normal and bruise more easily. MedlinePlus reports that spots that appear small and have a purple color may develop on the skin. These side effects, while seeming to be serious, generally are not. They should subside on their own.